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KMID : 0869620080250010054
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Journal of Korean Society of Hospital Pharmacists
2008 Volume.25 No. 1 p.54 ~ p.63
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Cho Dong-Sun
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Abstract
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Total Knee Replacement(TKR) surgery is an invasive procedure for those who have a late-stage knee joint disorder and cannot benefit from conventional drugs or conservative therapies. In the TKR surgery, the bone and the cartilage on the end of thigh bone(femur) and top bone(tibia) are removed to create exact surfaces to accommodate the implant. The end of two bones is then capped by special metals. A specially designed plastic, metal and ceramic knee replacement implant is placed to function as a new knee joint and enables a patient to move smoothly. This study shows the 3rd generation cephalosporins do not significantly reduce the rate of surgical site infection in comparison with 2nd generation cephalosporins. Although they seem to reduce the total days of hospital care, they did not reduce the total medication costs and significantly raised the antibiotics costs. A frequent use of the 3rd generation cephalosporin is closely related to the emergence of resistant bacterial strains, and may limit the choice of antibiotic treatment when serious infections like osteomyelitis occur. The study suggests solid facts against the abuse of broad spectrum antibiotics, which tend to be overused in Korean hospitals out of ungrounded worries for infection.
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KEYWORD
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Total Knee Replacement, 3rd generation cephalosporins 2nd generation cephalosporins, Antibiotics costs, Osteomyelitis
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